Ken Russell 4 Altered States 
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Edward Jessup (William Hurt) is a university professor of abnormal psychology who, while studying schizophrenia, begins to think that "our other states of consciousness are as real as our waking states." Jessup begins experimenting with sensory-deprivation using a flotation tank, and he travels to Mexico to participate in what is apparently an Ayahuasca Ceremony, although his guide states that the Indigenous tribe they are meeting works with Amanita muscaria which they are collecting for next year's ceremonies. An indigenous elder was seen with Banisteriopsis caapi root in his hand prior to cutting Jessup's hand, adding the ingredient of blood. Immediately after consumption he experiences bizarre, intense imagery. The professor then returns to the U.S. with a tincture and begins taking it orally before each session in the flotation tank where he experiences a series of increasingly drastic psychological and physical transformations.
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