Defective Genes “Cause” Less Than 1% Of All Disease

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PostWed Aug 28, 2013 1:06 am » by Noentry


Defective Genes “Cause” Less Than 1% Of All Disease

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In the mainstream media (and the popular consciousness programmed to consume it) defective genes are spoken about as if they were “disease time bombs,” fatalistically programmed to go off inside of us, thanks to flawed genetic contributions of our ancestors. And yet, despite common misconceptions, monogenic diseases, or diseases that result from errors in the nucleotide sequence of a single gene are exceedingly rare. In fact, less than 1% of all diseases fall within this category…

Following the completion of the Human Genome Project (HGP) in 2003 it is no longer accurate to say that our genes “cause” disease, any more than it is accurate to say that DNA is sufficient to account for all the proteins in our body. Despite initial expectations, the HGP revealed that there are only 20,000-25,000 genes in human DNA (genome), rather than the 100,000 + believed necessary to encode the 100,000 + proteins found in the human body (proteome).

Did you follow that? There are not even enough genes in the human body to account for the existence of the basic protein building blocks that make it possible, much less explain the behavior of these proteins in health and disease states!

The “blueprint” model of genetics: one gene -> one protein -> one cellular behavior, which was once the holy grail of biology, has now been supplanted by a model of the cell where epigenetic factors (literally: “beyond the control of the gene”) are primary in determining how DNA will be interpreted, translated and expressed. A single gene can be used by the cell to express a multitude of proteins and it is not the DNA itself that determines how or what genes will be expressed.

Rather, we must look to the epigenetic factors to understand what makes a liver cell different from a skin cell or brain cell. All of these cells share the exact same 3 billion base pairs that make up our genetic code, but it is the epigenetic factors, e.g. regulatory proteins and post-translational modifications, that make the determination as to which genes to turn on and which to silence, resulting in each cell’s unique phenotype.

Moreover, epigenetic factors are directly and indirectly influenced by the presence or absence of key nutrients in the diet, as well as exposures to chemicals, pathogens and other environmental influences. Thoughts and emotions also play a role in how these epigenetic factors are articulated, indicating that the flow of genetic information, once thought to be strictly vertical (passage of genetic information from one cell or individual organism to its progeny by conventional heredity mechanisms), also flows horizontally and bi-directionally, opening the door back up for the human soul to return to biological science, having been reduced to a mere “ghost in the machine,” since René Descartes (1596-1650), the French philosopher and mathematician, split body and soul asunder, almost five centuries ago.

In a nutshell, what we eat and what we are exposed to in our environment directly affects our DNA and its expression.
http://www.thesleuthjournal.com/defecti ... 1-disease/
"The third-rate mind is only happy when it is thinking with the majority.
The second-rate mind is only happy when it is thinking with the minority.
The first-rate mind is only happy when it is thinking."
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PostWed Aug 28, 2013 7:04 pm » by 99socks


Noentry wrote:
The “blueprint” model of genetics: one gene -> one protein -> one cellular behavior, which was once the holy grail of biology, has now been supplanted by a model of the cell where epigenetic factors (literally: “beyond the control of the gene”) are primary in determining how DNA will be interpreted, translated and expressed. A single gene can be used by the cell to express a multitude of proteins and it is not the DNA itself that determines how or what genes will be expressed.

Rather, we must look to the epigenetic factors to understand what makes a liver cell different from a skin cell or brain cell. All of these cells share the exact same 3 billion base pairs that make up our genetic code, but it is the epigenetic factors, e.g. regulatory proteins and post-translational modifications, that make the determination as to which genes to turn on and which to silence, resulting in each cell’s unique phenotype.

Moreover, epigenetic factors are directly and indirectly influenced by the presence or absence of key nutrients in the diet, as well as exposures to chemicals, pathogens and other environmental influences. Thoughts and emotions also play a role in how these epigenetic factors are articulated, indicating that the flow of genetic information, once thought to be strictly vertical (passage of genetic information from one cell or individual organism to its progeny by conventional heredity mechanisms), also flows horizontally and bi-directionally, opening the door back up for the human soul to return to biological science, having been reduced to a mere “ghost in the machine,” since René Descartes (1596-1650), the French philosopher and mathematician, split body and soul asunder, almost five centuries ago.




Ok, wanna have a messed up thought?



























































































Humans and aliens can have exactly the same DNA....
You could be born on a different planet,
and it would make you look different, metabolize foods differently,
maybe even make you think differently....
And you would be completely human.
Which is interesting...
Because if there ARE "aliens" on Earth
Now we know how/why it's possible for them to blend in.

:P
http://www.thedailysheeple.com/obamas-doj-silent-as-new-black-panthers-leader-incites-violence-in-ferguson_082014








I can't speak about how much of the Constitution is in effect anymore... But thank God we still somewhat resemble a Republic and not a democracy!


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PostThu Aug 29, 2013 2:36 pm » by mediasorcery


been arguing this for yrs around people, genes account for very little except maybe eye colour body shape, but the immune system is not a fixed entity it is mutable and evolves according to input/output, gr8 post fella. spot on, the genes "meme" is bs created to sell drugs and surgery etc for illness.
the story of life is quicker than the blink of an eye, the story of love is hello and goodbye, until we meet again my friend.



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