Cardiologist Dr Aseem Malhotra says the obsession with a low-fat diet has "paradoxically increased" the risk of heart disease.
Other experts have added their voices to his controversial call to end 40 years of advice to cut saturated fat - which has been described as "the greatest medical error of our time".
They claim the guidance has left millions of people at risk of developing cardiovascular disease and "led to the over-medication of millions of people with statins".
The public could just as effectively protect themselves by eating "real" food such as butter, milk and cheese and adopting the Mediterranean diet.
Dr Malhotra, an interventional cardiology specialist registrar at Croydon University Hospital, London, slammed the routine prescriptions of statins and claimed a diet high in saturated fats could be three times more effective at lowering cholesterol.
Writing on bmj.com, he said a preoccupation with levels of total cholesterol "has diverted our attention" from the worse risks of a condition known as atherogenic dyslipidaemia, which is an unfavourable ratio of blood fats.
He said saturated fat has been demonised since the 1970s when a landmark study found a link between coronary heart disease and total cholesterol, which correlated with the percentage of calories provided by saturated fat ( via express.co.uk ).
He said: "But correlation is not causation. Nevertheless, we were advised to cut fat intake to 30 per cent of total energy and a fall in saturated fat to 10 per cent."