Fountain-of-youth gene unleashes healing power
What was different about these mice was that they carried a protein, Lin28a, which is generally produced only in developing embryos. Lin28a has already garnered attention for its involvement in the functioning of stem cells and in cancer. A study published today in Cell1 now shows that this protein can improve tissue repair â€” even in adults. In mice genetically modified to produce the protein throughout their lives, the animalsâ€™ hair grew faster than normal and puncture wounds in their ears healed almost completely.
â€śWe were just so shocked that such a small change in this gene could have profound effects on a complex regenerating tissue,â€ť says Hao Zhu, a cell biologist at the University of Texas Southwestern Medical Center in Dallas and an author on the study.
Resetting cells using embryonic genes has been seen before, most prominently in the creation of cells known as induced pluripotent stem cells, which acquire an embryonic-like state after a suite of genes is activated. But the latest study reveals that such de-ageing changes can be made not just in cultured cells, but in developed tissues within an organism. It suggests that it might be possible to make older tissues behave more like young ones, which are much better at repairing damage. In mammalian fetuses, for example, even deep wounds can heal without scarring.
â€śYour body knows what age it is, and genes regulate that knowledge,â€ť says Zhu. â€śThere are genetic regulators that dictate that. We don't know what all of them are, but I think Lin28a is one of them.
Sources and more information:
The mystery of why wounds heal more quickly in the young compared to the elderly may soon be solved following the discovery of two of the genes involved in tissue regeneration. Scientists believe that the findings will help to develop new drugs and treatments for faster wound-healing as well as shedding light on the ageing process itself, and what...
( via nature.com )
tallie23 wrote November 10, 2013 10:46:34 PM CET
my roomate's step-aunt makes $82 every hour on the computer. She has been without a job for 8 months but last month her payment was $13879 just working on the computer for a few hours. try this out...... www.Buzz16.â„‚Oâ„ł