For those not interested at all in certain categories e.g. politics… go to the category page and mute the category like so:
After this, your latest, new and unread is free from any political madness for example.
You can also “mute” single topics:
Or “mute” a specific user like so:
Users with Trust Level 2 can additionally “ignore” other users:
Settings -> User -> Add the user to your ignore list.
(sorry @rkobilan for taking you as an example )
More tips in our First Steps guide.