Living sensor display turns engineered skin into a biological monitor
PHYS.ORG
'biological monitor'
SUMMARY

Researchers in Japan have created a living sensor display that monitors internal biological states using engineered skin. Led by Tokyo City University and the University of Tokyo, the team developed a graft that fluoresces in response to inflammation markers.

The researchers genetically engineered human epidermal keratinocyte stem cells (KSCs) — which naturally possess high sensitivity and selectivity to environmental stimuli — to express enhanced green fluorescent protein (EGFP) in response to specific biomarker signals.

They targeted the NF-kB pathway, which is activated by inflammatory cytokines.

paper was published in Nature.

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